Jpn. J. Appl. Phys. 49 (2010) 012701 (6 pages)  |Previous Article| |Next Article|  |Table of Contents|
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In vivo Ultrahigh-Resolution Ophthalmic Optical Coherence Tomography Using Gaussian-Shaped Supercontinuum

Masahiro Nishiura, Toshihiro Kobayashi¹, Muneyuki Adachi¹, Jun Nakanishi¹, Tokio Ueno¹, Yasuki Ito², and Norihiko Nishizawa³

(Received September 14, 2009; accepted October 22, 2009; published online January 20, 2010)

We have demonstrated the in vivo ultrahigh-resolution optical coherence tomography (OCT) imaging of the human eye using a Gaussian-shaped supercontinuum source. Using an ultrashort-pulse Ti:sapphire laser and a polarization-maintaining single-mode fiber, a linearly polarized, high-power, low-noise, Gaussian-shaped supercontinuum is generated in the wavelength region from 700 to 950 nm. For ophthalmic imaging, a wideband Gaussian-shaped supercontinuum with a bandwidth of 140 nm is generated at a center wavelength of 830 nm. The observed axial resolutions are 2.9 µm in air and 2.1 µm in tissue. The generated supercontinuum is combined with a modified ophthalmic OCT system, and sidelobe-free ultrahigh-resolution OCT images of the human retina and cornea are obtained.

URL: http://jjap.ipap.jp/link?JJAP/49/012701/
DOI: 10.1143/JJAP.49.012701

References

1. D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto: Science 254 (1991) 1178[Science].
2. W. Drexler, U. Morgner, R. K. Ghanta, F. X. Kartner, J. S. Schuman, and J. G. Fujimoto: Nat. Med. 7 (2001) 502.
3. J. G. Fujimoto: Nat. Biotechnol. 21 (2003) 1361.
4. W. Drexler: J. Biomed. Opt. 9 (2004) 47.
5. M. Wojtkowski, V. J. Srinivasan, T. H. Ko, J. G. Fujimoto, A. Kowalczyk, and J. S. Duker: Opt. Express 12 (2004) 2404.
6. J. G. Fujimoto, A. D. Aguirre, Y. Chen, P. R. Herz, P.-L. Hsiung, T. H. Ko, N. Nishizawa, and F. X. Kartner: Ultrashort Laser Pulses in Biology and Medicine (Springer, New York, 2007) Chap. 1.
7. E. J. Fernandez, B. Hermann, B. Povazay, A. Unterhuber, H. Sattmann, B. Hofer, and W. Drexler: Opt. Express 16 (2008) 11083.
8. B. Potsaid, I. Gorczynska, V. J. Srinivasan, Y. Chen, J. Jiang, A. Cable, and J. G. Fujimoto: Opt. Express 16 (2008) 15149.
9. W. Drexler, U. Morgner, F. X. Kartner, C. Pitris, S. A. Boppart, X. D. Li, E. P. Ippen, and J. G. Fujimoto: Opt. Lett. 24 (1999) 1221.
10. I. Hartl, X. D. Li, C. Chudoba, R. K. Ghanta, T. H. Ko, J. G. Fujimoto, J. K. Ranka, and R. S. Windeler: Opt. Lett. 26 (2001) 608.
11. B. Povazay, K. Bizeheva, A. Unterhuber, B. Hermann, H. Sattmann, A. F. Fercher, W. Drexler, A. Apolonski, W. J. Wadsworth, J. C. Knight, P. S. J. Russell, M. Vetterlein, and E. Scherzer: Opt. Lett. 27 (2002) 1800.
12. Y. Wang, Y. Zhao, J. S. Nelson, Z. Chen, and R. S. Windeler: Opt. Lett. 28 (2003) 182.
13. K. Bizheva, B. Povazay, B. Hermann, H. Sattmann, W. Drexler, M. Mei, R. Holzwarth, T. Hoelzenbein, V. Wacheck, and H. Pehamberger: Opt. Lett. 28 (2003) 707.
14. M. Wojtkowski, T. Bajraszewski, I. Gorczynska, P. Targowski, A. Kowalczyk, W. Wasilewski, and C. Radzewicz: Am. J. Ophthalmol. 138 (2004) 412.
15. M. Szkulmowski, M. Wojtkowski, T. Bajraszewski, I. Gorczynska, P. Targowski, W. Wasilewski, A. Kowalczyk, and C. Radzewicz: Opt. Commun. 246 (2005) 569[CrossRef].
16. S. Bourquin, A. Aguirre, I. Hartl, P. Hsiung, T. Ko, J. Fujimoto, T. Birks, W. Wadsworth, U. Büting, and D. Kopf: Opt. Express 11 (2003) 3290.
17. N. Nishizawa, Y. Chen, P. Hsiung, E. P. Ippen, and J. G. Fujimoto: Opt. Lett. 29 (2004) 2846.
18. Y. Wang, I. Tomov, J. S. Nelson, Z. Chen, H. Lim, and F. Wise: J. Opt. Soc. Am. A 22 (2005) 1492.
19. H. Wang, C. P. Fleming, and A. M. Rollins: Opt. Express 15 (2007) 3085.
20. H. Tu, D. L. Marks, Y. L. Koh, and S. A. Boppart: Opt. Lett. 32 (2007) 2037.
21. T. Hori, J. Takayanagi, N. Nishizawa, and T. Goto: Opt. Express 12 (2004) 317.